翻訳と辞書 Words near each other ・ Orotate phosphoribosyltransferase ・ Orotate reductase (NADH) ・ Orotate reductase (NADPH) ・ Orotava ・ Orotava Valley ・ Orote Field ・ Orote Historical Complex ・ Orote Peninsula ・ Orotelli ・ Orotermes ・ Orothalassodes ・ Orothalassodes falsaria ・ Orothalassodes pervulgatus ・ Orothamnus ・ Orotic acid ・ Orotic aciduria ・ Orotidine ・ Orotidine 5'-monophosphate ・ Orotidine 5'-phosphate decarboxylase ・ Orotina ・ Orotina (canton) ・ Oroton ・ Orotone ・ Orotrechus ・ Orotukan ・ Orou Gabé Orou Sego ・ Orou Gnonrou ・ Oroua ・ Oroua (New Zealand electorate) ・ Oroua County Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Orotic aciduria ： ウィキペディア英語版 Orotic aciduria Orotic aciduria refers to an excessive excretion of orotic acid in urine. It causes a characteristic form of anemia and may be associated with mental and physical retardation. Orotic acid is an intermediate product in pyrimidine synthesis pathway, a subsequent product of which plays a role in conversion between dihydrofolate and tetrahydrofolate. Orotic aciduria is associated with megaloblastic anemia due to decreased pyrimidine synthesis, which leads to decreased nucleotide-lipid cofactors needed for erythrocyte membrane synthesis in the bone marrow. ==Signs and symptoms== In addition to the characteristic excessive orotic acid in the urine, patients typically have megaloblastic anemia (UMP synthase deficiency) which cannot be cured by administration of vitamin B12 or folic acid. It also can cause inhibition of RNA and DNA synthesis and failure to thrive. This can lead to mental and physical retardation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Orotic aciduria」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.